The set focuses on the Underworld of Theros over the normal world of the plane, with a major plot point being the return of Klothys, the Therosian god of destiny. It features the planeswalker Elspeth Tirel and her torturer Ashiok.
The Gods are at war, and they bring their champions to fight. Elspeth breaks free and defeats Heliod with a weapon created from her past traumas. Klothys finds out about Elspeth escaping the Underworld so she is sending someone to bring her back to the Underworld or capture her.